No one in my family has cancer so I’m safe.

This idea is false. In fact, only 5-10% of all cancers are caused by inheriting defective genes from a parent or grandparent which can double or triple your chances of being diagnosed with cancer. In the African environment where there is stigmatization of the disease, people often discount a cancer diagnosis; hiding it from relatives to avoid ridicule or attributing it to conditions caused by evil spirits. It is also important to know that abnormal genes can skip generations and so the fact that none of your immediate family members have cancer does not rule out the possibility of cancer running in your family. The opposite is also true; having the genes passed on to you doesn’t guarantee your developing cancer. Several environmental factors like smoking, lack of exercise and unhealthy eating habits affect whether or not the abnormal gene will translate into cancer.

What if there really isn’t any history of cancer in my family? Up to 80% of people diagnosed with cancer have no family history of the disease at all. This notwithstanding, researchers warn against disregarding your chances of developing this dreadful disease. Risk factors like age, race and lifestyle factors should influence your decision to screen and the frequency of such screening to allow for early detection of cancer. It is highly recommended that you choose healthy lifestyle options to further decrease your chances of developing cancer. Finally, do not be so busy as to disregard any changes in your overall health. Regular self-checks and visits to the doctor are ways you can make your health a priority.


9 cancer facts you need to know

  1. Cancer is a group of disease caused by uncontrolled growth of the body’s cells into abnormal cells which can spread to other regions of the body.
  2. Cancer can affect any part of your body even including your eye and tongue. While in most areas it presents as a lump which can be detected by self, in other parts of the body like the stomach, blood and lung symptoms aren’t readily observed. Screening and detection saves the day in such cases.
  3. Only 5-10% of cancers are inherited. The vast majority of cancers can be attributed to lifestyle factors.
  4. Cancer can be prevented. Certain practices such as smoking have been linked to onset of cancer. Thus, avoiding tobacco use is a key way to prevent lung and other cancers. Also, a diet rich in fruits and vegetables offers protection against a variety of cancers of the gastrointestinal tract. Other ways to prevent cancer include exercising and having a good sleep.
  5. In developing countries, many are predisposed to cancers arising from infections such as cervical cancer from the Human Papilloma Virus (HPV) and Liver cancer from Hepatitis B and C infections. In 2008, approximately 85% of women diagnosed with cervical were from developing countries
  6. Chemotherapy and Radiotherapy are the conventional ways of treating cancers. Research into other forms of treatment such as immunotherapy is underway and being considered for cancer management.
  7. Any two people who have the same type of cancer can have different treatment regimen which depends on the aggressive nature of cancer, age, overall health, among other factors.
  8. Doctors do not use the term “cure’ for cancer. This is because although an individual can be cancer-free after treatment, there is always the possibility that the cancer can come back (recurrence). The term remission is used for an individual who has no cancer left after treatment
  9. In Ghana, the commonest cancers are breast, cervix and ovary for women and prostate, liver and stomach for men.

Sugar and Cancer

The link between cancer and sugar has been investigated by various researchers from as far back as the 1960s. Some researchers have looked at the sources of the sugars to determine effect on onset and disease progression. For instance, in a large prospective study spanning 20years, the association between intake of dietary carbohydrates and colorectal cancer was assessed in 6107 participants. Men who consumed sucrose from sources such as table sugar, sweetened beverages, alcohol etc. had a slightly higher risk of developing colorectal cancer compared to the control group. This has been corroborated by other studies which have established a link between high intake of sugars and increased incidence of bowel, rectal, colon, lung and pancreatic cancers1,2,3,4,5. A number of these associations were also linked to other factors such as level of physical activity, body mass index (BMI) and intake of other fatty foods. Conversely, eating of unrefined sugars as derived from raw and cooked vegetables was seen to be protective against colorectal cancer. Here again, fruits although protective were less so in comparison to vegetables possibly due to their relatively higher sugar content6.

In an experimental setup to determine the relationship between sugars and tumour growth, human prostate tumour cells were implanted in murine models and observed over 9 weeks. At the end of the period, mice who were fed a high carbohydrate diet had larger tumours compared to those on low-carbohydrate diets7. This observation seems to suggest that high sugar content contributes to growth of tumour cells. In the tumour microenvironment, there is metabolic competition between tumour and normal cells over sugars. T cells – which help to fight and clear tumours – require lactate, a form of sugar, for their effector function of tumour clearance. However, glucose utilization by tumours restrict T-cell function thereby allowing cancer progression8. When Seely et al. analyzed the relationship between sugar consumption and deaths from breast cancer, it was seen that older women with disease who consumed high amounts of sugar were likelier to die from breast cancer than younger women with disease9.

From the above, the following deductions can be made: regular intake of refined sugars from sweetened beverages and pastries increases your risk of cancer whereas a balanced amount of vegetables and fruits can significantly protect you from developing cancer; after receiving a cancer diagnosis, an individual who takes in high glucose foods can fuel the growth of tumours resulting in poorer prognosis. Thus, consulting with a registered nutritionist can help one to create and maintain healthy nutritional habits while receiving cancer treatment.

References

  1. Michaud, D.S., Fuchs, C.S., Liu, S., Willett, W.C., Colditz, G.A. and Giovannucci, E., 2005. Dietary glycemic load, carbohydrate, sugar, and colorectal cancer risk in men and women. Cancer Epidemiology and Prevention Biomarkers14(1), pp.138-147.
  2. Baghurst, P.A., McMichael, A.J., Slavotinek, A.H., Baghurst, K.I., Boyle, P. and Walker, A.M., 1991. A case-control study of diet and cancer of the pancreas. American Journal of Epidemiology134(2), pp.167-179.
  3. Bristol, J.B., Emmett, P.M., Heaton, K.W. and Williamson, R.C., 1985. Sugar, fat, and the risk of colorectal cancer. Br Med J (Clin Res Ed)291(6507), pp.1467-1470.
  4. Bostick, R.M., Potter, J.D., Kushi, L.H., Sellers, T.A., Steinmetz, K.A., McKenzie, D.R., Gapstur, S.M. and Folsom, A.R., 1994. Sugar, meat, and fat intake, and non-dietary risk factors for colon cancer incidence in Iowa women (United States). Cancer Causes & Control5(1), pp.38-52.
  5. De Stefani, E., Deneo‐Pellegrini, H., Mendilaharsu, M., Ronco, A. and Carzoglio, J.C., 1998. Dietary sugar and lung cancer: A case‐control study in Uruguay.
  6. Franceschi, S., Favero, A., La Vecchia, C., Negri, E., Conti, E., Montella, M., Giacosa, A., Nanni, O. and Decarli, A., 1997. Food groups and risk of colorectal cancer in Italy. International Journal of Cancer72(1), pp.56-61.
  7. Venkateswaran, V., Haddad, A.Q., Fleshner, N.E., Fan, R., Sugar, L.M., Nam, R., Klotz, L.H. and Pollak, M., 2007. Association of diet-induced hyperinsulinemia with accelerated growth of prostate cancer (LNCaP) xenografts. Journal of the National Cancer Institute99(23), pp.1793-1800.
  8. Chang, C.H., Qiu, J., O’Sullivan, D., Buck, M.D., Noguchi, T., Curtis, J.D., Chen, Q., Gindin, M., Gubin, M.M., van der Windt, G.J. and Tonc, E., 2015. Metabolic competition in the tumor microenvironment is a driver of cancer progression. Cell162(6), pp.1229-1241.
  9. Seely, S. and Horrobin, D.F., 1983. Diet and breast cancer: the possible connection with sugar consumption. Medical hypotheses11(3), pp.319-327.

Foods that cause gas and bloating

Some foods, no matter how healthy can sometimes result in swelling or accumulation of gas in the belly or abdomen. This condition known as bloating can either be a nuisance or an indication of a more serious condition.In general, eating large quantities of food, eating quickly and intake of fatty and rich foods have been linked to bloating. Today’s post however is looking at temporary bloating caused by some food groups and what replacements are available for such.

FOOD THAT CAUSE GAS AND BLOATING WHAT TO EAT INSTEAD
Beans Pinto beans and black beans (may be more digestible, especially after soaking) Alternatively, replace beans with grains, meat or quinoa
Lentils Light colored lentils are generally lower in fiber than darker ones, and may therefore cause less bloating.
Carbonated drinks Plain water is always best. Other healthy alternatives include herbal and fruit teas and fruit-flavored still water.
Wheat Gluten-free alternatives to wheat, such as pure oats, quinoa, buckwheat, almond flour and coconut flour.
Cruciferous vegetable family includes broccoli, cauliflower, cabbage, brussels sprouts, etc. Spinach, cucumbers, lettuce, sweet potatoes and zucchini.
Onions Try using other herbs and spices in your cooking, such as thyme, parsley, chives or basil.
Barley also found in malted drinks and beers Refined barley, like pearl or scotch barley. Replace with other grains or pseudo-cereals like oats, brown rice, quinoa or buckwheat.
Rye (cereal grain that is related to wheat) Replace with other grains or pseudo-cereals like oats, brown rice, quinoa or buckwheat.
Dairy Products People who are lactose intolerant can sometimes handle cream and butter, or fermented dairy like yogurt.

Lactose-free milk products are also available.

Other alternatives to regular milk include coconut, almond, soy or rice milks.

Apples Cooked apples may be easier to digest than fresh ones.

Other fruits, such as bananas, grapefruit, mandarins, oranges or berries, etc.

Garlic Try using other herbs and spices in your cooking, such as thyme, parsley, chives or basil.
Sugar alcohols (used to replace sugar in sugar-free foods and chewing gums). Common types include xylitol, sorbitol and mannitol. Erythritol is also a sugar alcohol, but it is easier on digestion than the ones mentioned above. Stevia is also a healthy alternative to sugar and sugar alcohols.
Beer/ Malt/ Fizzy Drinks Water is always the best beverage, but if you are looking for alcoholic alternatives then red wine, white wine or spirits may cause less bloating.

TRAMADOL IS NOT TIC-TAC

The recent surge in the misuse and abuse of opioid analgesics by the Ghanaian youth is alarming and very disheartening. Codeine containing antitussives are being mixed with various beverages, alcoholic and non-alcoholic and gulped down like shots of vodka while capsules of tramadol are swallowed like tic-tac. These practices can in part be attributed to ignorance about the systemic effects of such drugs on one’s health thus, necessitating this brief write-up.

Opioids are DRUGS indicated for Pain and used sometimes in extreme cases of cough, diarrhoeal diseases and other diagnosed conditions. Like all drugs, they are to be taken with caution and expert advice must always be sought. Opioids are only prescribed in the event of moderate to severe pain for the management of such. Hence when the pain is mild, Aspirin, Paracetamol and the Non-Steroidal Anti-inflammatory drugs (NSAIDS) such as Ibuprofen, Diclofenac, Naproxen etc. are preferred unless the patient has a condition that doesn’t allow for any of the aforementioned drugs to be used.

Like all drugs, Opioids have their side effects. These include:

  • Mood changes – feeling high, euphoria, somnolence
  • Sedation, Drowsiness, inability to concentrate
  • Depression
  • Gastrointestinal issues- stomach issues that can arise include Nausea and vomiting, Constipation, abdominal cramping among others. Constipation is usually the worst due to difficulty in its management. – which is
  • Urinary retention
  • Urticaria, Itching,
  • Respiratory depression – breathing become slowed, shallow and may even cease in severe cases
  • Brain damage due to reduced Oxygen to the brain from Respiratory depression.

After Tramadol or codeine pills are taken, they interact with brain receptors leading to the alteration of pain. In addition, dopamine activity is increased and contributes to feelings of reward in an individual. Such feelings reinforce the user’s desire to continually use the pills, albeit unconventionally, causing him/her to develop Dependence with time. Over time, the effects a particular dose or number of pills give decreases in a process known as Tolerance and might result in various cases of over-dose and drug misuse until an individual is completely addicted. More often than not a user does not recognize symptoms of addiction despite the negative consequences and adverse effects experienced. This corroborates the words of Dr. Russell Portenoy, a renowned pain specialist who defined addiction as a behavioural pattern characterized by loss of control over drug use, compulsive drug use, and continued use of a drug despite harm.

The psychosocial effects of abusing opioids are strained relationships with loved ones, diminished finances, decreased self-worth, among others. The short-lived feelings of ecstasy experienced with opioid abuse pales in significance to the long term detrimental effects on one’s health, wealth and overall wellbeing. That being said, our encouragement is to desist from taking drugs unless prescribed by a registered health professional. In addition, if you are caught in a web of opioid abuse, then please speak to your doctor, pharmacist or trusted health professional and you would be amazed by the help available to you.

By Caleb Oppong – Wiafe, Registered Pharmacist.


Could your bloated belly be a sign of Ovarian Cancer?

What will you do about a persistent bloated tummy? Should you be concerned? Ovarian cancer is among the first 5 cancers causing deaths in women in sub-Saharan Africa1. Evidence from a population based cancer registry in Ghana recorded more female cancers (69.6%) than male; with ovarian cancer being the 3rd commonest (11.3%)4. Similar results were observed in a large scale study in Nigeria11 where Ovarian cancer was reported as the second commonest (30.5%) with a higher proportion compared to other gynaecological cancers. The age of incidence was also relatively lower compared to other gynaecological cancers like cervical and endometrial10. It is estimated that more than 70% of women with ovarian cancer receive a diagnosis at a later stage of the disease2 resulting in poorer prognosis and thus, increased mortalities. One of the primary reasons for this delay is due to the painless growth of ovarian tumours3 which has earned it the infamous “silent killer” tag. This notwithstanding, it is believed that certain abdominal and urinary symptoms should be given a closer look to help in the early detection of ovarian cancers.

In a large case-control study to determine the symptoms associated with ovarian cancer, abdominal and gastrointestinal symptoms such as bloated tummy, abdominal pains and constipation were the most cited symptoms. It was observed that participants who reported persistence of these symptoms developed ovarian tumours compared to those who observed these symptoms 1-2times per month2. These findings have been confirmed by several studies with other symptoms such as feeling full quickly and nausea adding to the list6,7. Because these symptoms are not gynaecological in nature, more often than not, they are ignored or missed. This necessitated signing of a consensus statement to encourage primary care physicians to recognize these symptoms which suddenly arise with increasing severity as possible ovarian cancer signs.

What should you do? Due to changing dietary habits and the adoption of western lifestyles, many African women have central or abdominal obesity. Unfortunately, this is sometimes viewed as signs of good living and very few take active steps to report increase in abdominal girth or bloating. It is worthy to note that the symptoms discussed above could be indicative of other conditions such as bladder infections and irritable bowel syndrome and that; other factors such as genetics, parity (pregnancy and birth), urinary symptoms and age at menopause affect ovarian carcinogenesis8,9. Nevertheless, one should keep in mind that the rate of survival decreases from 80-90% to 20-30% when the disease is diagnosed late. The encouragement is to see your primary physician when you experience sudden increase in abdominal bloating and crampy abdominal pain with increasing severity. A longer interval between onset of symptoms and reporting results largely in poor prognosis. Remember, early diagnosis saves the day!

References:

  1. http://globocan.iarc.fr/Pages/fact_sheets_population.aspx
  2. Goff, B.A., Mandel, L.S., Drescher, C.W., Urban, N., Gough, S., Schurman, K.M., Patras, J., Mahony, B.S. and Andersen, M.R., 2007. Development of an ovarian cancer symptom index. Cancer109(2), pp.221-227.
  3. Smith, L.H., Morris, C.R., Yasmeen, S., Parikh‐Patel, A., Cress, R.D. and Romano, P.S., 2005. Ovarian cancer: can we make the clinical diagnosis earlier?. Cancer104(7), pp.1398-1407.
  4. Laryea, D.O., Awuah, B., Amoako, Y.A., Osei-Bonsu, E., Dogbe, J., Larsen-Reindorf, R., Ansong, D., Yeboah-Awudzi, K., Oppong, J.K., Konney, T.O. and Boadu, K.O., 2014. Cancer incidence in Ghana, 2012: evidence from a population-based cancer registry. BMC cancer14(1), p.362.
  5. Goff, B.A., Mandel, L.S., Melancon, C.H. and Muntz, H.G., 2004. Frequency of symptoms of ovarian cancer in women presenting to primary care clinics. Jama291(22), pp.2705-2712.
  6. Bankhead, C.R., Kehoe, S.T. and Austoker, J., 2005. Symptoms associated with diagnosis of ovarian cancer: a systematic review. BJOG: An International Journal of Obstetrics & Gynaecology112(7), pp.857-865.
  7. Rossing, M.A., Wicklund, K.G., Cushing-Haugen, K.L. and Weiss, N.S., 2010. Predictive value of symptoms for early detection of ovarian cancer. Journal of the National Cancer Institute102(4), pp.222-229.
  8. https://academic.oup.com/jnci/article/99/18/1359/925194
  9. Parazzini, F., Franceschi, S., La Vecchia, C. and Fasoli, M., 1991. The epidemiology of ovarian cancer. Gynecologic oncology43(1), pp.9-23.
  10. Nkyekyer, K., 2000. Pattern of gynaecological cancers in Ghana. East African medical journal77(10).
  11. Yakasai, I.A., Ugwa, E.A. and Otubu, J., 2013. Gynecological malignancies in Aminu Kano teaching hospital Kano: A 3 year review. Nigerian journal of clinical practice16(1), pp.63-66.

Rainbow-Coloured Foods: Yellow and Orange

Food Colour: ORANGE/YELLOW

So if you have been watching this space you will realise that I have been briefly highlighting the colour of food: specifically fruits and vegetables and their health benefits. Today, is the turn of the orange and yellow hue. Foods of these colours include yellow melons, pineapples, oranges, lemons, carrots, sweet potatoes, star fruits, etc.

The orange and yellow hues are rich in carotenoids1, a class of naturally occurring plant chemicals or phytonutrients2. These are also responsible for the red in fruits and vegetables. The health benefits that come with eating orange, yellow and red fruits and vegetables are as a result of the ability of the carotenoids in these fruits and vegetables to act as provitamins (can be converted to actual vitamins inside the human body such as Beta carotene into vitamin A) and an antioxidant3 (Read the previous article to get the summarised list of benefits for eating antioxidants: https://www.sgmccancercentre.com/2018/03/rainbow-coloured-foods-red-2/).

I would like to end here by quoting the conclusion of a 2017 academic article in the World Journal of Gastroenterology written by Lee et al: “Vegetables and fruits intake from various colour groups may protect against colorectal cancer.”4

By Frema Asiedu (Registered Nutritionist)

References:

  • Slavin, J. L., & Lloyd, B. (2012). Health Benefits of Fruits and Vegetables. Advances in Nutrition, 3(4), 506–516. http://doi.org/10.3945/an.112.002154
  • Jessie Szalay 2015. What Are Carotenoids? Retrieved on 19th March 2017 from https://www.livescience.com/52487-carotenoids.html
  • Liu, R. H. (2013). Health-Promoting Components of Fruits and Vegetables in the Diet. Advances in Nutrition, 4(3), 384S–392S. http://doi.org/10.3945/an.112.003517
  • Lee, J., Shin, A., Oh, J. H., & Kim, J. (2017). Colors of vegetables and fruits and the risks of colorectal cancer. World Journal of Gastroenterology, 23(14), 2527–2538. http://doi.org/10.3748/wjg.v23.i14.2527

Rainbow-Coloured Foods: Red

Food Colour: RED

By Frema Asiedu (Registered Nutritionist)

So what makes your fruit or vegetable red?….Anthocyanins and Anthocyanidins1. These are water soluble naturally occurring pigments that CAN change colour when the pH increases. So basically when the pH is acidic (pH <7) the fruit or vegetable containing these pigments remain red. But, when the pH becomes basic (pH >7) they turn…wait for it…PURPLISH BLUE1.

Yes, all your red fruits such as: watermelon, strawberries, cherries, raspberries, apples; and vegetables like tomatoes, red peppers2, etc. fall in this bracket. Have you noticed how ‘sobolo’ (Ghanaian spicy drink made from the brew of red hibiscus flowers) comes out red when made but after drinking it, you tongue turns purplish blue? This is because the pH in your mouth is somewhat basic (“6.2-7.6 with 6.7 being the average pH”3). Now why should we care…?

It will interest you to know that these pigments that were traditionally extracted and used as natural food colorants or dyes have massive health benefits that include anti-oxidant properties, anti-microbial activity, improved visual and neurological health, and protection from some non-communicable diseases1.

Why are antioxidants important?When we breathe in oxygen, our body uses it to produce energy.In so doing it produces “molecular species capable of independent existence that contains an unpaired electron in an atomic orbital.”4 These are simply called free radicals. Free radicals are unstable and very reactive causing a lot of damage5.Uncontrolled free radicals have been linked to many chronic illnesses such as cardiovascular diseases (heart diseases, stroke, intestinal ischemia), cancer, aging, neurological disorders (Alzheimer’s disease, Parkinson’s disease, muscular dystrophy), diabetes4, 7,8. In addition, many inflammatory diseases such as: (arthritis, vasculitis, glomerulonephritis, lupus erythematous, adult respiratory diseases syndrome), hemochromatosis, gastric ulcers, hypertension and preeclampsia, and many others7 can be linked to the damage from free radicals. Anti-oxidants however, reduce the damage done to the body due to generation of free radicals6.Isn’t it interesting to note that, by including some amount of red-coloured foods in your diet, your risk for developing these conditions are markedly reduced due to the many beneficial properties these foods possess?

Our admonition: Don’t forget to add some red to your food this week. Eat that tomato!

References:

  1. Khoo HE, Azlan A, Tang ST, Lim SM. 2017. Anthocyanidins and Anthocyanins: Colored Pigments as Food, Pharmaceutical Ingredients, and the Potential Health Benefits. Food & Nutrition Research. Aug 13; 61(1):1361779. doi: 10.1080/16546628.2017.1361779.
  2. Derocha, G. 2011. Using Color as a Guide to a Better Diet: 9 Health Benefits of Red Fruits and Vegetables. A Healthier Michigan. Retrieved on 12th March 2018 from https://www.ahealthiermichigan.org/2011/03/22/using-color-as-a-guide-to-a-better-diet-9-health-benefits-of-red-fruits-and-vegetables/
  3. Baliga S, Muglikar S, and Kale R. Salivary pH: A Diagnostic Biomarker. Journal of Indian Society of Periodontology: 17(4): 461–465. doi:  10.4103/0972-124X.118317
  4. Lobo V, Patil A, Phatak A, Chandra N. 2010. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacognosy Reviews;4(8):118-126. doi:10.4103/0973-7847.70902.
  5. Cheeseman KH, Slater TF. 1993. An Introduction to Free Radicals Chemistry. British Medical Bulletin;49:481–93.
  6. com. 2018. Medical Definition of Antioxidant. Retrieved on 12th March 2018 from https://www.medicinenet.com/script/main/art.asp?articlekey=11291
  7. Lovell MA, Ehmann WD, Buffer BM, Markesberry WR. 1995. Elevated ThiobarbituricAcid Reactive Substances and Antioxidant Enzyme Activity in the Brain in Alzheimer’s Disease. Neurology;45:1594–601
  8. Stefanis L, Burke RE, Greene LA. 1997. Apoptosis in Neurodegenerative Disorders. Current Opinion in Neurology;10:299–305.

Do microwave ovens cause cancer?

No. Microwave ovens Do Not cause cancer. There is no established research that proves a link between the use of microwave ovens and development of cancer.

How do microwaves work? Electromagnetic energy, which is similar to radio waves, from microwaves heat up the water molecules from food. The bouncing around of these heated water molecules result in warming of our food. Since microwaving does not cause changes in food that aren’t introduced by other methods of cooking, it doesn’t make food any likelier to cause cancer than other forms of cooking like boiling, frying, etc.  Here are two points to note:

  • Food heated or cooked in the microwave does not become radioactive and so will not cause damages to your DNA leading to cancer.
  • The microwave oven and its walls are not radioactive once the oven is switched off.

The following precautions can be taken into account when using a microwave:

  1. follow the manufacturer’s instructions on safe use of microwave, for instance ensuring that the door is well shut.
  2. Use only containers that are labelled microwave-safe. Do not use plastic wraps or take-out containers as they may melt and leak into food.
  3. For even cooking, stir food periodically at optimum temperature and times
  4. Lift or Leave the lid of food slightly ajar while microwaving.

To summarize, the idea that microwaves cause cancer is a myth. While it is important to exercise caution in their use, microwave ovens are safe for cooking and heating up our foods.

Useful links:

https://www.fda.gov/ForConsumers/ConsumerUpdates/ucm048953.htm

https://www.arpansa.gov.au/understanding-radiation/radiation-sources/more-radiation-sources/microwave-ovens

https://www.csiro.au/en/Research/Health/Food-safety/Microwave-oven-safety